Does Estrogen + Progestin Increase the Risk of Lung Cancer?

Posted on February 28, 2010 by David Oliver

According to "Lung Cancer and Hormone Replacement Therapy: Association in the Vitamins and Lifestyle Study" published in the Journal of Clinical Oncology, long term use of estrogen and progestin (> 10 yrs) produced a 48% increase in lung cancer and typically advanced disease at that. Interestingly, those taking estrogen alone experienced no increase in risk.

The hazard ratio was only 1.48 with a confidence interval from 1.03 to 2.12 meaning the reported result suggests at best a hypothesis for further testing and not a presumed causal relationship.

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