Interestingly, there's a dramatic difference in risk between those with heavy and those with moderate exposure to chrysotile asbestos and, in fact, the small increase in risk to those with moderate exposure did not reach statistical significance. See "Lung Cancer Mortality From Exposure to Chrysotile Asbestos and Smoking: A Case-Control Study Within a Cohort in China".
Now I must explain the Subtle Approach. There are three occasions on which we cannot use the Direct Opening, and these we must consider carefully: (1) when our cause is discreditable, that is, when the subject itself alienates the hearer from us; (2) when the hearer has apparently been won over by the previous speakers of the opposition; (3) or when the hearer has become wearied by listening to the previous speakers.
- Cicero "Ad Herennium"
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