Smoking and H. pylori are at the top of the list. Further down you'll find much weaker risks like alcohol, diabetes, metabolic syndrome and having a non-O blood type. Here's the newest review: "Epidemiology of Pancreatic Cancer: An Update".
Now I must explain the Subtle Approach. There are three occasions on which we cannot use the Direct Opening, and these we must consider carefully: (1) when our cause is discreditable, that is, when the subject itself alienates the hearer from us; (2) when the hearer has apparently been won over by the previous speakers of the opposition; (3) or when the hearer has become wearied by listening to the previous speakers.
- Cicero "Ad Herennium"
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