There's a growing body of evidence pointing to early disruption of gut microbiota via antibiotics as a cause of inflammatory bowel disease and Crohn's disease later in life. For the newest see "Association Between the Use of Antibiotics in the First Year of Life and Pediatric Inflammatory Bowel Disease" in this month's American Journal of Gastroenterology.
Now I must explain the Subtle Approach. There are three occasions on which we cannot use the Direct Opening, and these we must consider carefully: (1) when our cause is discreditable, that is, when the subject itself alienates the hearer from us; (2) when the hearer has apparently been won over by the previous speakers of the opposition; (3) or when the hearer has become wearied by listening to the previous speakers.
- Cicero "Ad Herennium"
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